The United States failed to qualify for the World Cup for the first time since 1986 after losing to Trinidad & Tobago and a controversial goal for Panama.
The US started the night in the third qualifying place but ended up fifth after losing 2-1.
Panama jumped up to third after an 88th-minute winner against Costa Rica to reach their first World Cup finals.
However, it was their opening goal that caused debate with Gabriel Torres’ header not appearing to cross the line.
The 52nd-minute equaliser came from a corner with Torres’ effort hitting the post and as Blas Perez tried to force the ball over the line, Ticos defender Ronald Matarrita looked to have cleared it.
However, despite complaints from the visitors, referee Walter Lopez of Guatemala gave the goal.
Source: BBC Sport